OmniBank e-Biology
Our OmniBank e-Biology program has been designed to accelerate academic and non-profit research of human gene function by offering academic and non-profit researchers the opportunity to purchase knockout mouse lines made from our OmniBank library.Additional features and benefits of our OmniBank e-Biology program include:
- Standardized qualification protocols confirming the disruption of the trapped gene (greater than 99% success rate) summarized in a comprehensive quality control report;
- Detailed information describing the site of the insertional mutation and the retroviral gene trap construct used (including restriction map); and
- Gene specific genotyping protocols for each OmniBank clone.
- Rapid access to hundreds of previously generated knockout mouse lines, many of which have been created using homologous recombination.
We make mouse lines available under this program at fees starting at $30,000, depending upon the contract options selected. Due to commercial proprietary obligations, mouse lines for certain OmniBank embryonic stem cell clones may not be available under our OmniBank e-Biology program.
Selected references from our Academic clients.
Search OmniBank for clones targeting your gene of interest.
- Behavioral and neurochemical alterations in mice lacking the RNA-binding protein translin. J Neurosci. 2006 Feb
- Critical function for SIP, a ubiquitin E3 ligase component of the beta-catenin degradation pathway, for thymocyte development and G1 checkpoint. Immunity. 2006 Jan
- Glucose metabolism in mice lacking muscle glycogen synthase. Diabetes. 2005 Dec
- GABARAP is not essential for GABA receptor targeting to the synapse. Eur J Neurosci. 2005 Nov
- Nucleophosmin is required for DNA integrity and p19Arf protein stability. Mol Cell Biol. 2005 Oct
- Reduced N-acetylaspartate levels in mice lacking aralar, a brain- and muscle-type mitochondrial aspartate-glutamate carrier. J Biol Chem. 2005 Sep
- Regulation of in vitro and in vivo immune functions by the cytosolic adaptor protein SKAP-HOM. Mol Cell Bio. 2005 Sep
- Exercise capacity of mice genetically lacking muscle glycogen synthase: in mice, muscle glycogen is not essential for exercise. J Biol Chem. 2005 Apr
- The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR. Cell. 2005 Jan 28
- Mice deficient in the axonemal protein Tektin-t exhibit male infertility and immotile-cilium syndrome due to impaired inner arm dynein function. Mol Cell Biol. 2004 Sep
- Loss of BBS proteins causes anosmia in humans and defects in olfactory cilia structure and function in the mouse. Nat Genet. 2004 Sep
- Abnormal cardiac development in the absence of heart glycogen. Mol Cell Biol. 2004 Aug
- Null mutation of calpain 3 (p94) in mice causes abnormal sarcomere formation in vivo and in vitro. Hum Mol Genet. 2004 Jul
- Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice. Mol Cell Bio. 2004 Jun
- Dwarfism and impaired gut development in insulin-like growth factor II mRNA-binding protein 1-deficient mice. Mol Cell Biol. 2004 May
- Translin-associated factor X is post-transcriptionally regulated by its partner protein TB-RBP, and both are essential for normal cell proliferation. J Biol Chem. 2004 Mar
- Intron disruption of the annexin IV gene reveals novel transcripts. J Biol Chem. 2003 Oct
- Mice deficient for testis-brain RNA-binding protein exhibit a coordinate loss of TRAX, reduced fertility, altered gene expression in the brain, and behavioral changes. Mol Cell Biol. 2003 Sep
- Congenital diaphragmatic hernia, kidney agenesis and cardiac defects associated with Slit3-deficiency in mice. Mech Dev. 2003 Sep
- Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo. Proc Natl Acad Sci USA 2003 May.
- Axon Regeneration in Young Adult Mice Lacking Nogo-A/B Neuron. 2003 Apr.
- Characterization of the WAVE1 knock-out mouse: implications for CNS development. J Neurosci. 2003 Apr
- Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc Natl Acad Sci USA 2003 Apr.
- Role for the BRCT protein 53BP1 in maintaining genomic stability. J Biol Chem 2003 Apr.
- The absence of mitochondrial thioredoxin 2 causes massive apoptosis, exencephaly, and early embryonic lethality in homozygous mice. Mol Cell Biol 2003 Feb.
- Mdm4 (Mdmx) Regulates p53-Induced Growth Arrest and Neuronal Cell Death during Early Embryonic Mouse Development Molecular and Cellular Biology, 2002 Aug
- p38 is essential for the assembly and stability of macromolecular tRNA synthetase complex: implications for its physiological significance. Proc Natl Acad Sci USA 2002 Jun.
- Increased vascular permeability in C1 inhibitor-deficient mice mediated by the bradykinin type 2 receptor. J Clin Invest., 2002 Apr.
- Disruption of Ini1 leads to peri-implantation lethality and tumorigenesis in mice. Mol Cell Biol., 2001 May.
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